Sokolowski Lab

Sokolowski Lab

Genes, Environment & Behaviour

Bryon Hughson

Byron
bryon.hughson@utoronto.ca

Previous Degree

  • H.B.Sc. Biology (University of Waterloo, 2006)

Degree Pursuing

  • Ph.D., University of Toronto, Department of Ecology and Evolutionary Biology

Presentations

LIMES conference on insect metabolism, 2013 (poster):expression in the corpora cardiaca influences response to nutrient stress in Drosophila melanogaster

GRC2012 poster – foraging expression in neuroendocrine tissue influences response to nutrient stress in Drosophila melanogaster

Publications

MacMillan, H.A. and B.N. Hughson. 2014. A high-throughput method of hemolymph extraction from adult Drosophila without anesthesia. J. Ins. Physiol. 63: 27-31.

Hughson, B.N., Pham, V. and M.B. Sokolowski. Natural variation in foraging behaviour. In: Behavioural Genetics of the Fly (Drosophila melanogaster). Ed. J. Dubnau. Cambridge University Press, 2014: 714-751.

Donlea, J., Leahy, A., Thimgan, M.S., Suzuki, Y., Hughson, B.N., Sokolowski, M.B., and P.J. Shaw. 2012. Foraging alters resilience/vulnerability to sleep disruption and starvation in Drosophila. PNAS 109(7): 2613-8.

Lucas, C., Hughson, B.N., and M.B. Sokolowski. 2010. Job switching in ants: role of a kinase. Commun Integr Biol 3(1): 6-8.

Research Summary

Central to the theme of my research is the idea that feeding behaviour is intrinsically linked with metabolism. Metabolism incurs an energetic cost which can be met for short periods of time through the catabolism of internal energy stores contained in muscle and fat body tissues. However, over longer periods of time these internal energy stores must be replenished so that metabolic homeostasis can be restored. To this end, feeding behaviour is modified in response to changes in metabolism, such that a hungry fly will search for and ingest food. My thesis work aims to characterize a role for the foraging gene in the corpora cardiaca (CC) as a regulator of larval and adult feeding-related behaviour. Through the examination of changes in physiological and molecular characters resulting from the manipulation of foraging in the CC, this work has implicated the foraging gene as a key player in the regulation of metabolic homeostasis in Drosophila melanogaster.

 

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